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1. Chiappori F, Ferrario MG, Gaiji N, Fantucci P Docking of estrogen and genistein like molecular library on Estrogen Receptor alpha and beta Meeting: BITS 2005 - Year: 2005 Full text in a new tab Topic: Unspecified Abstract: Estrogen replacement therapy is one of the most efficient treatment of menopausal symptoms. Unfortunately, despite the benefits of estrogenic therapy evidence exists of increasing number of cases of reproductive tissue cancer. This lead to a strong interest in discovering new compounds that display the benefits of estrogens avoiding such risks. We decided to apply a virtual high throughput screening, based on docking simulations, for the identification of new possible selective receptor compounds. |
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2. Chiappori F, Ferrario MG, Gaiji N, Fantucci P Design of Selective Compounds for the Estrogen Receptors: A Molecular Docking and Machine Learning Study Meeting: BITS 2006 - Year: 2006 Full text in a new tab Topic: Combinatorial libraries and drug design Abstract: Missing |
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3. Ferrario MG, Chiappori F, Ferrario MG, Gaiji N, Fantucci P Molecular dynamic study of the ligand binding domain of estrogen receptor alfa and beta Meeting: BITS 2005 - Year: 2005 Full text in a new tab Topic: Unspecified Abstract: Estrogen Receptor belongs to the Nuclear receptor family, there are two different currently known subtypes Era and Erb. Levels and proportion of the two subtypes differs in different target cells. We can hypotheses a different pharmacological activity upon ligand binding. The aim of this work is the investigation through molecular dynamics simulations, on both the subtypes a and b of the estrogen receptor, of possible differences among them and for the study of their dynamical behaviour. |
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4. Ferrario MG, Chiappori F, Gaiji N, Fantucci P Alpha and Beta Estrogen Receptors: Molecular Modelling and Conformational Analysis through Molecular Dynamics Meeting: BITS 2006 - Year: 2006 Full text in a new tab Topic: Protein structure Abstract: Missing |